KG 41 SOYBEAN

41-Azido-41-de­oxy­rapamycin

The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bond...

Rev_iss_web_ene_13036_23-7 41..41

G. S. Collins and Y. Le Manach Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, and Departments of Anesthesia and Clinical Epidemiology and Biostatistics, Michael DeGroote School of Medicine, Faculty of Health Sciences, Population Health Research Institute, McMaster University and the Perioperati...

COMPLEXES OF INJECTIVE kG-MODULES

Let G be a finite group and k be a field of characteristic p. We investigate the homotopy category K(Inj kG) of the category C(Inj kG) of complexes of injective (= projective) kG-modules. If G is a p-group, this category is equivalent to the derived category Ddg(C(BG; k)) of the cochains on the classifying space; if G is not a p-group it has better properties than this derived category. The ord...

Plasma levels of intranasal midazolam at 0.4 mg/kg and 0.2 mg/kg doses.

Five young adult Rhesus monkeys were included in this study. The weight of the animals ranged from 3.4 to 4.0 kg, with a mean of 3.6 kg. Each animal was restrained and anesthetized with ketamine HC1 at 25 mg/kg IM. An intravenous fluid of 5% dextrose and water with 1/4 normal saline was initiated and profused at a maintenance rate. Each monkey received intranasal midazolam (VersedTM, Roche Phar...

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